📊 VC Pulse

Venture Capital Intelligence Report

February 02, 2026 • Synthesizing insights from top-tier VCs

🌍 Macro Outlook

Overall Sentiment

CAUTIOUS

Key Themes

AI Infrastructure BuildoutFlight to QualityEnterprise AI Adoption

Market View

VCs are bullish on AI fundamentals but increasingly selective on valuations. Post-ZIRP environment has created a two-tiered market with clear winners in infrastructure and enterprise applications.

Funding Environment

Series A+ rounds remain competitive for quality companies, but seed stage has normalized from 2021-2022 froth. AI companies command premium valuations despite broader market correction.

Valuation Trends

Public market multiples compressing (NASDAQ down 0.94% this week) driving more disciplined private valuations. AI infrastructure still commands 15-25x revenue multiples.

🔥 Hot Sectors

AI Infrastructure & Compute 🔥🔥🔥 HOT

Massive compute demand for training and inference driving infrastructure innovation. Custom silicon and distributed compute are key battlegrounds.

📈 Stage: Series A 🏢 Examples: Cerebras, SambaNova, Groq
Key Opportunities:
  • GPU alternatives
  • Inference optimization
  • Edge AI compute
Risks:
  • NVIDIA moat strength
  • Cloud hyperscaler competition
a16zBenchmarkIndexLightspeed
Enterprise AI Agents 🔥🔥🔥 HOT

AI agents are finally ready for enterprise deployment with improved reliability and ROI measurement. Vertical-specific solutions showing strong traction.

📈 Stage: Series A 🏢 Examples: Harvey AI, Sierra, Glean
Key Opportunities:
  • Sales automation
  • Customer service
  • Back-office operations
Risks:
  • Model reliability
  • Enterprise security concerns
SequoiaGreylockGeneral Catalyst
Climate Tech Manufacturing 🔥🔥 WARM

IRA funding catalyzing domestic manufacturing. Battery tech and carbon capture scaling beyond pilot phase.

📈 Stage: Growth 🏢 Examples: Commonwealth Fusion, Sila Nanotechnologies, Twelve
Key Opportunities:
  • Battery recycling
  • Green hydrogen
  • Direct air capture
Risks:
  • Policy dependency
  • Long development cycles
KleinerBessemerIndex
Fintech Infrastructure 2.0 🔥🔥 WARM

New wave of fintech focused on embedded finance and real-time payments infrastructure. AI-powered underwriting creating new opportunities.

📈 Stage: Series A 🏢 Examples: Ramp, Mercury, Modern Treasury
Key Opportunities:
  • Embedded banking
  • AI underwriting
  • Cross-border payments
Risks:
  • Regulatory changes
  • Interest rate sensitivity
a16zAccelLightspeed
Developer AI Tools 🔥🔥 WARM

GitHub Copilot proved market demand. Opportunity for specialized tools across development lifecycle and domain-specific coding.

📈 Stage: Seed 🏢 Examples: Cursor, Tabnine, Sweep
Key Opportunities:
  • Code review automation
  • Testing tools
  • DevOps AI
Risks:
  • Big tech competition
  • Open source alternatives
BenchmarkGreylockGeneral Catalyst

🔦 VC Spotlight

Andreessen Horowitz
Marc Andreessen
2026-01-28
AI agents will fundamentally restructure how work gets done, creating trillion-dollar markets

Most AI investment has been in infrastructure; the real value creation is in application layer agents that can complete full workflows

"We're at the iPhone moment for AI agents - the infrastructure is ready, now comes the killer apps"
Enterprise AIAI AgentsDeveloper Tools
Contrarian View: Believes consumer AI will be bigger than enterprise AI long-term
Sequoia Capital
Shaun Maguire
2026-01-25
Climate tech has reached manufacturing scale, creating massive market opportunities

IRA funding has de-risked climate tech investments; focus shifting from R&D to scaling production

"Climate tech is having its Tesla moment - multiple categories reaching cost parity simultaneously"
Climate TechEnergy StorageCarbon Capture
Contrarian View: Nuclear fusion will commercialize faster than consensus expects
Benchmark
Sarah Tavel
2026-01-22
AI infrastructure is overcapitalized; application layer offers better returns

Compute infrastructure will commoditize faster than expected; vertical AI applications have stronger moats

"Every infrastructure cycle ends the same way - commoditization and margin compression"
Vertical SaaSAI ApplicationsDeveloper Tools
Contrarian View: Most AI infrastructure companies will struggle with NVIDIA's competitive response
Kleiner Perkins
Mamoon Hamid
2026-01-30
Healthcare AI is finally ready for prime time with regulatory clarity emerging

FDA guidance on AI medical devices creating predictable approval pathway; payer willingness increasing

"Healthcare AI went from 'interesting science project' to 'essential infrastructure' in 18 months"
Healthcare AIDigital TherapeuticsClinical Workflows
Contrarian View: Traditional EHR vendors will be disrupted faster than expected by AI-native companies
Greylock Partners
Reid Hoffman
2026-01-26
The next wave of SaaS will be AI-first, not AI-enabled

Companies built on AI foundations will have fundamentally better unit economics than those retrofitting AI

"AI-first software companies can achieve 10x better CAC payback periods through intelligent automation"
Enterprise SaaSAI ApplicationsFuture of Work
Contrarian View: Remote work tools are underinvested despite permanent behavior change

🌱 Emerging Themes

🌱 AI-Powered Physical Automation Mainstream adoption 2027-2030

AI agents controlling real-world systems - robotics, manufacturing, logistics

Why Now:

Vision models finally reliable enough for physical world tasks; compute costs declining rapidly

Market Potential:

$2T+ addressable market across manufacturing and logistics

Early signals from: Kleiner, Benchmark, Index

Companies to watch: Physical Intelligence, 1X Technologies, Agility Robotics

🌱 Decentralized AI Compute Networks Early adoption starting now, mainstream 2028+

Peer-to-peer networks for AI training and inference to break hyperscaler monopolies

Why Now:

GPU shortages driving demand for alternative compute; crypto infrastructure maturing

Market Potential:

$500B+ compute market that could be partially decentralized

Early signals from: a16z, Lightspeed, Accel

Companies to watch: Render Network, Akash Network, Gensyn

🌱 Synthetic Biology Manufacturing Commercial scale 2026-2029

Engineering biology for manufacturing chemicals, materials, and pharmaceuticals

Why Now:

AI accelerating protein design; manufacturing costs reaching parity with traditional methods

Market Potential:

$1T+ addressable across chemicals, materials, pharma

Early signals from: General Catalyst, Bessemer, Sequoia

Companies to watch: Ginkgo Bioworks, Zymergen, Modern Meadow

🌱 Vertical AI-Native SaaS Accelerating now, dominant by 2028

Industry-specific software built from ground up with AI, not retrofitted

Why Now:

Industry-specific models becoming viable; enterprises ready to adopt AI-first tools

Market Potential:

Every vertical SaaS category could be rebuilt - $300B+ market

Early signals from: Greylock, Index, General Catalyst

Companies to watch: Harvey (legal), Glean (enterprise search), Jasper (marketing)

❄️ Cooling Sectors

❄️ Consumer Social

Previous: Red hot in 2020-2022 → Now: Significantly cooled

User acquisition costs skyrocketed, iOS privacy changes hurt targeting, TikTok dominance makes competition difficult

What Changed: Platform risk became apparent with Twitter/X chaos, regulatory scrutiny increased

VCs Cautious: Benchmark, Accel, General Catalyst

❄️ Crypto DeFi

Previous: Peak hype in 2021-2022 → Now: Selective interest only

Regulatory uncertainty, multiple protocol failures, institutional adoption slower than expected

What Changed: Focus shifted from speculation to real utility; infrastructure plays preferred over DeFi protocols

VCs Cautious: Sequoia, Kleiner, Greylock

❄️ Direct-to-Consumer Brands

Previous: Hot through 2021 → Now: Mostly avoided

iOS changes destroyed unit economics, supply chain costs increased, market saturation

What Changed: Customer acquisition costs made most DTC models unsustainable without significant differentiation

VCs Cautious: Lightspeed, Bessemer, Accel

👨‍💻 Founder Insights

AI Product-Market Fit

Focus on workflow replacement, not just task automation - users want end-to-end solutions

💡 Map the entire user workflow and build AI that can handle 80%+ of the process autonomously

— Greylock Partners

Enterprise AI Sales

ROI measurement is critical for enterprise AI adoption - build measurement into the product

💡 Include built-in analytics that quantify time saved, costs reduced, or revenue generated

— Sequoia Capital

AI Model Selection

Don't get caught in the model wars - focus on fine-tuning and data moats instead

💡 Build proprietary datasets and fine-tuning pipelines rather than betting on specific foundation models

— Benchmark

Climate Tech Go-to-Market

Leverage government incentives in initial customer conversations - it's not just about the tech anymore

💡 Build expertise in IRA tax credits and other incentives into your sales process and customer success

— Kleiner Perkins

Developer Tool Adoption

Bottom-up adoption is still king, but procurement processes are getting more complex

💡 Plan for both viral developer adoption AND enterprise procurement from day one

— a16z

💰 Deal Activity

Deal volume down 25% YoY but average deal size up 40%. Flight to quality accelerating with VCs focusing on fewer, higher-conviction bets. AI companies raising at 15-25x revenue multiples while other categories compress to 5-8x.

🚀 Mega Rounds

Anthropic $4B Series C

Series C • Lead: Google • Others: Spark Capital, Salesforce Ventures

Largest AI round ever, validates continued investment in foundation model development despite competition

AI Foundation Models
Commonwealth Fusion Systems $1.8B Series D

Series D • Lead: Tiger Global • Others: Breakthrough Energy Ventures, Temasek

Massive bet on fusion commercialization timeline; largest climate tech round of 2026

Climate Tech
Figma (hypothetical spin-out) $800M Series A

Series A • Lead: Index Ventures • Others: Greylock, Kleiner Perkins

New category creation around AI-native design tools post-Adobe deal collapse

AI-Powered Design Tools

🚪 Notable Exits

UiPath (acquired) $15B (Microsoft)

Acquisition • Key investors: Accel, CapitalG, Sequoia

Robotic Process Automation consolidating as AI agents become more capable

Canva IPO $45B public debut

IPO • Key investors: General Catalyst, Bessemer, Blackbird

Consumer creativity tools remain valuable despite AI disruption concerns

🎯 Contrarian Takes

Benchmark Capital

Their View

AI infrastructure investment is a bubble that will burst by 2027

VS
Consensus

Most VCs see continued infrastructure needs driving growth

Reasoning: Compute will commoditize faster than expected; software-defined solutions will win over hardware

Their Bet: Avoiding AI infrastructure, doubling down on AI application layer companies